Pneumococcal Cell Wall Polysaccharide (CWPS Multi)

Pneumococci produce a conserved sugar group antigen (CWPS, C-Ps, teichoic acid). Recent research has shown at least two different variants, based on the quantity of phosphorylcholine (CWPS1 and CWPS2) (article 2). CWPS Multi consists of 50% CWPS1 and 50% CWPS2.

Product Description

Pneumococcal CWPS sugar (1 and 2) is produced by purifying the sugar from well-defined non-capsule-bearing pneumococcal reference strains. The protein and DNA/RNA impurity is minimal, less than 3% of the total quantity.

Clinical Relevance

Streptococcus pneumoniae expresses a number of different sugars on the cell surface. Most sugars are in the cell capsule, which defines the 92 different pneumococcal serotypes currently known. In addition to the type-specific capsule sugars, all pneumococci also express a group antigen, referred to as the cell wall polysaccharide (CWPS). CWPS is found in two different forms, depending on the quantity of phosphorylcholine per sugar unit. The capsule sugars are found in existing vaccines, partly in conjugate vaccine for children, but also in pure sugar vaccines for adults.

Expert knowledge in producing

Broad range of pneumococcal antigens

For adsorption material in immunological investigations such as ELISA antibody assay

We offer experienced technical support

How to use

Pneumococcal CWPS Multi is used as adsorption material in immunological investigations such as ELISA antibody assays, to evaluate whether any vaccination/revaccination is desirable. When CWPS Multi is used, adsorption with the 22F capsule, as recommended by WHO for ELISA (article 1), is not required.

Product Range

Article
number
ProductPacking
68866CWPS Multi10 mg

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IFU

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CWPS

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    Articles:

    1)  https://www.vaccine.uab.edu/uploads/mdocs/ELISAProtocol(007sp).pdf
     
    2) Skovsted IC, Kerrn MB, Sonne-Hansen J, Sauer LE, Nielsen AK, Konradsen HB, Petersen BO, Nyberg NT, Duus JO. Purification and structure characterization of the active component in the pneumococcal 22F polysaccharide capsule used for adsorption in pneumococcal enzyme-linked immunosorbent assays. Vaccine. 2007 Aug 29;25(35):6490-500.

    Pneumococcal Cell Wall Polysaccharide (CWPS)

    Pneumococci produce a conserved sugar group antigen (CWPS, C-Ps, teichoic acid).

    Product description

    CWPS-like sugars are found also on the oral streptococci S. mitis and S. oralis. Since humans are constantly affected by oral streptococci and non-invasive pneumococci (carriers), humans normally have a high level of non-protective antibodies against CWPS.

    Clinical Relevance

    Streptococcus pneumoniae expresses a number of different sugars on the cell surface. Most sugars are in the cell capsule, which defines the 91 different pneumococcal serotypes currently known. In addition to the type-specific capsule sugars, all pneumococci also express a group antigen, referred to as the cell wall polysaccharide (CWPS). CWPS is found in two different forms, depending on the quantity of phosphorylcholine per sugar unit. The capsule sugars are found in existing vaccines, partly in conjugate vaccine for children, but also in pure sugar vaccines for adults.

    Expert knowledge in producing

    Broad range of pneumococcal antigens

    For adsorption material in immunological investigations such as ELISA antibody assay

    We offer experienced technical support

    How to use

    Pneumococcal CWPS is used as adsorption material in immunological investigations such as ELISA antibody assays, to evaluate whether any vaccination/revaccination is desirable.

    Product Range

    Pneumococcal CWPS are produced by purifying the sugar from a non-capsule-bearing pneumococcus. The protein and DNA/RNA impurity is minimal, less than 3% of the total quantity.

    Article
    number
    ProductPacking
     3459 CWPS10 mg 

    Downloads

    Please find the available downloads here.

    IFU

    Click on the link below to download the IFU.

    CWPS

    Contact

    Please, reach out if you have questions, comments or requests.