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QuantiFERON® TB-Gold Plus

QuantiFERON® TB-Gold Plus is an ELISA test for the detection of M. tuberculosis in immunocompetent individuals. The analysis is particularly relevant in those who have received the BCG vaccine, as the analysis, in contrast to skin tests with tuberculin (Mantoux), can distinguish between infection with M. tuberculosis and vaccination.

Clinical relevance

QuantiFERON® TB-Gold Plus is an ELISA test for the detection of M. tuberculosis in immunocompetent individuals, for example, as part of infection detection, screening of high-risk groups, in special cases for the detection of active tuberculous disease and before treatment with immunosuppressive drugs. In the case of infection with M. tuberculosis, the immune response is predominantly cell mediated. In infected immunocompetent individuals, stimulation of blood with specific antigens (ESAT 6, CFP 10 and TB 7.7) will cause T lymphocytes to release the cytokine interferon gamma, which is detected by ELISA.

QuantiFERON-TB Gold Plus is the first TB blood test to receive certification under the European Union’s new In Vitro Diagnostic Medical Devices Regulation (IVDR).

Product description

QuantiFERON® TB-Gold Plus consists of an ELISA kit and blood collection tubes, which can be ordered separately. For sampling, four blood collection tubes are used: 1x Nil; 2x TB Ag and 1x Mitogen. The tubes are delivered as a combined package or in bulk. In the laboratory, up to 58 tests can be performed per ELISA kit. SSI Diagnostica distributes QuantiFERON®TB-Gold Plus in Denmark, Iceland, Norway and Sweden on behalf of QIAGEN.


  • Detection of infection with M. tuberculosis
  • Result within 24 hours
  • Distinguishes between infection with M. tuberculosis and BCG vaccination
  • Can be easily repeated – no booster phenomenon
  • Only one patient visit (compared to Mantoux test)
  • High reproducibility
  • Objective reading (95% CI 98-100%)
  • >99% specificity and >89% (95% CI 83-93%) sensitivity

Detect TB with confidence – more than 1700 clinical and scientific studies

Advancing the science of TB testing with innovative CD8 +T-cell technology

Highest specificity of any test for tuberculosis infection

For use as an aid in the detection of Mycobacterium tuberculosis (TB) infection

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